We are Evolutionary Biologics. Our science and technologies change lives, our products create external beauty and internal wellness, while our community strives for mental health, longevity, and a better quality of life!
Ultimately, through our educational efforts, we strive to create and sustain an evolved bio-wellness culture that we refer to as the EVO (EVOlved) Generation: a progressive population that aspires to establish homeostasis through a balanced mind, body and cell transformative lifestyle. All the while utilizing our msc exosome product line to help equip the body to operate as initially designed and optimize its functionality for the best possible quality of life.
EXO Series is an allogeneic Wharton's Jelly MSC-derived exosome product. Manufactured using our proprietary isolation and purification technologies. The natural cell origin of exosomes enables improved efficacy, biocompatibility, and reduced immunogenicity. In addition, EXO Series extensive characterizations, consistency, and potency assays, assure quality throughout the production process.
Introducing EXO RNA™ Neurobiologics and EXO RX™ Regenerative Aesthetics
MSC Exosomes promote reconstruction in cutaneous wound repair by regulating collagen ratios and fibroblast differentiation to mitigate scar formation. Therefore, the application of MSC Exosomes may be a novel therapeutic approach for scarless wound repair. Exosomes stimulate tissue growth, regenerate damaged tissues, and play a significant role in shortening healing time.
Sourced from Mesenchymal Stem Cells (MSC’s) EXO RNA™ offers superior regenerative benefits. Preclinical studies indicate that the naturally occurring proteins, messenger RNA, and microRNA within MSC Exosomes improve the function of aging, injured or diseased cells, tissue, and organs. As an ideal vehicle for delivery, exosomes can reach cells in parts of the body that many drugs cannot and have the ability to cross the blood-brain barrier.
Regenerative Aesthetics refers to the application of regenerative medicine principles in aesthetic or cosmetic treatments, products, and services. EXO RX™ is sourced from Mesenchymal Stem Cells and derived from umbilical cord lining (considered the super-highway of peptides). With over 300 growth factors and 30 forms of collagen, this biologic offers superior healing and regenerative benefits.
Exosomes are nano-sized extracellular vesicles, ranging 30-100 nanometers in diameter, secreted from the membranes of many cells, in this case, MSCs (Mesenchymal Stem Cells). They consist of lipids, proteins, nucleic acids and are acellular. Studies have confirmed that these extracellular vesicles have beneficial effects on inflammation, autoimmunity and regeneration, and contain over 300 growth factors responsible for wound repair and tissue regeneration.
Mesenchymal Stem Cells (MSCs) are human placenta and umbilical cord lining derived cells with self-renewing ability and can differentiate into various cell lineages. Multiple studies have reported that MSCs could elicit therapeutic effects via differentiation and/or secretion of factors such as growth factors, cytokines, and chemokines.
Neutrophil growth factors in MSCs are a type of leukocytes, or white blood cells. They play an important role in the immune system of the body, and they are one of the first blood cells to be sent to the site of infection as they can digest and break down pathogens and other bad guys such as prions and viruses. They are the most abundant type of leukocytes / white blood cells in MSCs.
Transdermal delivery is a painless method of delivering biologics systemically by applying it topically onto intact and healthy skin. The biologic initially penetrates through the stratum corneum and then passes through the deeper epidermis and dermis without accumulation in the dermal layer. When the MSC Exosomes reach the dermal layer, they become available for systemic absorption, and studies have shown that when a healthy cell sends an MSC Exosome to an unhealthy cell, the damaged cell begins to repair and regenerate itself; this cell-to-cell communication is called paracrine signaling.
Transdermal delivery has many advantages over other conventional routes of drug delivery. First, it can provide a non-invasive alternative to the application, thus circumventing issues such as needle phobia. Second, exosomes are 30 to 100 nanometers in diameter and are ideally suited for cutaneous delivery which is always the first significant obstacle to overcome in topical application.
The skin is the largest organ of the body. Yet, it's so superficial and constantly exposed to environmental toxicity and harmful radiation from the sun, the primary cause of aging skin. It's reflected through wrinkles, fine lines, large pores, and uneven pigmentation, and up to now, there hasn't been a practical non-invasive approach to correcting these issues.
The topical products currently being used to combat the aging of the skin don't have the regenerative properties necessary to penetrate to the deepest layers where the problem exists. As a result, they act like band-aids rather than solve the problem, which causes the patient to seek treatment for the same issue repeatedly.
Most skin rejuvenation techniques represent a controlled injury to the skin that stimulates a wound healing response and increases epidermal thickness and dermal collagen with better fibers.
While there are many innovative modalities in the market, none restore tissue function at a cellular level like MSC Exosomes. With over 300 growth factors, a full spectrum of peptides, and 30 forms of collagen, this biologic will ensure your patient’s consistent long-term results with tighter, younger-looking skin.
Neurobiologics refers to the application of biologics for neurodegenerative diseases, spinal cord injuries, and a host of neurological disorders. MSC Exosomes have the ability to cross the blood-brain barrier and deliver neurotrophic and regenerative growth factors to the areas of injury and inflammation.
Can EXO RNA™ Benefit Neurodegenerative Diseases?
Research has shown that MSC Exosomes can penetrate the blood-brain barrier and stimulate neuronal differentiation, neuronal growth, and suppress inflammatory processes within the brain tissue. These extracellular vesicles provide a primary mode of cell-to-cell communication by delivering proteins, lipids, and RNA to target cells. MSC Exosomes are found associated with neurodegenerative diseases, which are characterized by progressive degeneration of neurons.
The EVO Series is a minimally manipulated human allograft designed for homologous use. Comprised of two unique products derived from Wharton’s Jelly and other superior tissue types containing the highest therapeutics quality bioactive biomolecules. The extracellular matrix components in each tissue make these biologics robust in efficacy and ideal for musculoskeletal injuries and a full spectrum of applications.
Introducing EVO JEL™ Orthobiologics and EVO HYBRID™
Orthobiologics refers to the application of biologics for musculoskeletal injuries. These substances have the ability to heal bones, joints, muscles, and tendons. Orthobiologics can heal areas of tissue damage without the risks, complications, and downtime associated with traditional orthopedic surgery.
EVO JEL™ Orthobiologics Therapy
EVO JEL™ is especially effective in orthopedics because it provides cushioning and structural support for tissue and joints while addressing widespread inflammation and modulating an abnormal immune response.
Biologics are transforming medicine and is the fastest-growing sector in the pharmaceutical industry, with total revenues reaching up to $163 billion. Biologics provide safe solutions in many areas of unmet medical need, and their growth is expected to continue, especially in regenerative therapy. The efficacy and safety of these products and the ability to treat previously untreatable diseases are the single most significant influencing factor in the growth of this market.
EVO JEL™ is derived from Wharton’s Jelly of the human umbilical cord and is a gel-like tissue with unique characteristics of providing structural support, cushioning, and lubrication in the body. As a result, it can be used as an alternative to assist with musculoskeletal injuries, ailments involving tissue and joints in both acute and chronic settings.
WHAT DOES EVO JEL™ HAVE TO DO WITH PAIN?
When EVO JEL™ is delivered directly into an affected joint, it starts signaling cells to return to healthy function. It sends proteins into the walls of the cells telling the cells how to regulate themselves. There are two stages to the body’s response. In the first stage, which happens almost immediately, the inflammatory response is turned off. In the second stage, MSCs use paracrine signaling to tell the cells to regulate themselves, leading to long-term relief.
At Evolutionary Biologics, we are committed to quality and safety first!
Our biologics are manufactured at cGMP compliant FDA Certified labs using clean rooms and ISO 3 and ISO 7 technology and produced by highly trained scientists and engineers. As a result, we have total control over all the steps involved in our product development process to achieve high safety, purity, potency, viability, and reproducibility. Furthermore, all tissue donors go through stringent screening and testing following FDA guidelines. In addition, all of our products are third-party tested to ensure safety, efficacy, and consistency, batch to batch.
We invite you to collaborate on this breakthrough science and technology and evolve your practice with the most comprehensive education in regenerative medicine.
Over 95% of the world’s population has health problems, with over a third having more than five ailments. As you get older, your wound healing and tissue repairing capabilities decrease exponentially, and the pain associated with the damaged tissue seems to stay forever. New evidence indicates that a progressive decline in stem cell frequency and function may significantly contribute to the conditions related to aging. However, our EVO HYBRID™ proprietary formulation may help to jumpstart your own body’s natural healing power to relieve the pain and bring your body back to homeostasis.
EVO HYBRID™ is a proprietary blend of umbilical cord tissue, placental tissue, and amniotic membrane. This product contains the highest therapeutic quality bioactive biomolecules of Wharton’s Jelly derived (MSCs) mesenchymal stem cells and its extracellular matrix. In addition, these tissues exhibit a plethora of growth factors, exosomes, peptides, and cytokines that play a major role in modulating tissue homeostasis, immunomodulation, and cell to cell signaling for regeneration.
The unique proprietary blend of these superior tissue types allows EVO HYBRID™ to be used universally across a full spectrum of applications.
Wharton’s Jelly may be preferred over other regenerative medicine tissue-types because it contains a higher concentration mesenchymal stem cellular tissue (MSCs), growth factors, high molecular weight hyaluronic acid, peptides, exosomes, extracellular matrix and has a more regenerative power than other tissue-types. Making it an excellent option for regeneration, healing, pain reduction and inflammation.
Wharton’s Jelly is a gel-like tissue that has unique characteristics of providing structural support, cushioning, and lubrication in the body. It can be used as an alternative to assist with musculoskeletal injuries, ailments involving tissue and joints in both acute and chronic settings.
The global hair restoration size is anticipated to reach USD 13.6 billion by 2028, and Exosomal Therapy is taking the industry by storm!
Exosome therapy is a less expensive alternative to hair replacement surgery. This non-invasive treatment option increases hair thickness, fills in a receding hairline, and treats baldness as well as severe alopecia. According to the American Academy of Dermatology, androgenic alopecia is the most common cause of hair loss in both men and women.
increase growth and thickness
The global hair restoration size will reach USD 13.6 billion by 2028, and Exosomal Therapy is taking the industry by storm!
MSC Exosome therapy is a less expensive alternative to hair replacement surgery. This non-invasive treatment option increases hair thickness, fills in a receding hairline, treats baldness as well as severe alopecia.
Hair growth produced by MSC Exosomes is independent of aging hair. As the scalp ages, naturally, grown hair might fall off. But stimulated hair due to MSC Exosomes would resist all hormonal changes, making hair growth a permanent solution.
MSC Exosomes reduce the shrinking and growth of brittle hair strands (miniaturization). From there, without treatment, hair strands continue [shrinking] after each telogen phase until growth ceases to complete.
Many hair care products and treatments help prolong hair growth. However, none of them can treat at a cellular level like exosomes. As a result, the hair growth cycle remains intact longer while hair strands become thicker and healthier.
The latest from the world of biologics.
Biologics are transforming medicine and is the fastest-growing sector in the pharmaceutical industry, with total revenues reaching up to $163 billion.
Mesenchymal Stem Cells (Immunosuppressant) and regulatory T cells (Tregs) are both potent immune modulators.
The National Institutes of Health estimates over 50 million Americans suffer from Autoimmune Disease, and that number is increasing every year.
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